LABORATORY FACILITIES AND EQUIPMENT
The pharmacology department has a new research/teaching laboratory and a special lab for microscope experiments. Besides some basic apparatus, the labs are equipped with the following:
Tissue/organ-bath set containing 8 units with computerized read-out
Drugs can be tested for antagonistic and agonistic activity on blood vessels and muscular strips. Also unknown components like plant extracts and isolates can be tested for pharmacological activity with the possibility to unravel the responsible mechanisms.
Open-column chromatography with UV detection and fraction collection
Chromatography is a powerful method to separate components from complex solutions like plant extracts. Isolation of the component responsible for a pharmacological activity may provide a cheap and safer alternative for treatment of disease or the development of a new drug.
High-pressure Liquid Chromatography (HPLC) with Ultraviolet (UV) detection
Like the open-column chromatography, HPLC can be used for the isolation of components from plant extracts. It is more precise than the open-column system but only small quantities can be separated in single runs.
Secondly, HPLC is a powerful technique for quantitative analysis. Many drugs and endogenous markers of disease can be measured in complex solutions like plasma and urine using HPLC with UV detection. Pharmacokinetic drug studies and effect studies in humans and animals are within reach.
The pharmacology shares an animal facility with the department of Physiology and Anatomy. Mainly rats and mice are used for the different pharmacological experiments during practical and research.
Metabolic cages with fraction collectors
Urine of mice and rats can be collected using metabolic cages. To measure the time-course of drug excretion or endogenous markers of disease, the urine can be collected in separate fractions over time.
For real time imaging of fluorescent labels in living cells and for detection of fluorescent stained targets in tissue.
Tissue culture stove
The stove allows incubation of tissue and culturing of (mammal) cells and microbes is at different temperatures.